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Solving the puzzle of inducing organ transplant acceptance with the use of less life-long pharmacological immunosuppression would achieve a major milestone in medicine. A potential missing piece in solving this complex puzzle may be the application of cell therapy, whereby regulatory cell populations produced ex vivo could be administered near the time of transplantation to fundamentally reset the immune response in favour of transplant acceptance.
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During the therapy with immunosuppressive drugs the whole immune system is impaired and a myriad of side-effects arise. Thus, patients maintained on conventional immunosuppressive treatment suffer the consequences of drug toxicity, the development of chronic rejection, reduced resistance to infections, and a high rate of cancer occurrence. Besides these important side effects, financial costs can be high for the House party laws Tullinge and for health care systems.
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Improvements in treatment for these patients is imperative. Based on the ONE Study panels, expert flow cytometry labs have designed and optimized the marker and dye selections in DuraClone IM panels for use in clinical research studies.
Preventing immunological rejection of transplanted organs without the need for long-term use of pharmacological immunosuppression Single in Lidkoping study a primary objective. New transplant research should concentrate on early strategies that support long-term immunological acceptance of transplants, allowing for at least a reduction in the use of general immunosuppression.
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The ONE Study applies the novel concept of cell therapy to human clinical organ transplantation. This cooperative project aims at developing and trialling various immunoregulatory cell products in organ transplantation recipients, allowing a wtudy comparison of the safety, clinical practicality and therapeutic efficacy of each cell type.
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